We have recently characterized SCAI (Suppressor of Cancer Cell Invasion), a transcriptional modulator regulating cancer cell motility through suppression of MAL/SRF dependent gene transcription. We show here that SCAI is expressed in a wide range of normal human tissues and its expression is diminished in a large array of primary human breast cancer samples indicating that SCAI expression might...

A new site-specific endonuclease has been isolated from Streptomyces caespitosus and named ScaI. Based on analysis of sequences around the restriction sites in pBR322 and pBR325, the recognition sequence of ScaI endonuclease was deduced to be a new hexanucleotide 5'-AGTACT-3'. The cleavage site was determined by comparing the ScaI-cleaved product of a primer-extended M13mp18-SCA DNA, which cont...

SCAI is embarking on a new strategic planning process. Its goal is to determine the course SCAI should take over the next 3-5 years, and to position SCAI, its members and their patients for continued success in coming decades. Put simply, we are aiming for both longand short-term success. During the past several months SCAI leaders and staff have sought input from members, other societies, indu...

MicroRNAs (miRNAs) play critical roles in hepatocellular carcinoma (HCC) progression and are key determinants of prognosis. In this study, we found that miR-425-5p was elevated in HCC and correlated with poor prognostic clinicopathological features and low post-operative long-term survival. Multivariate survival analysis indicated that miR-425-5p expression was an independent risk factor for ov...

In response to growing U.S. interest, the Society for Coronary Angiography and Interventions recently formed a Transradial Committee whose purpose is to examine the utility, utilization, and training considerations related to transradial access for percutaneous coronary and peripheral procedures. With international partnership, the committee has composed a comprehensive overview of this subject...

Even though introspection, reflection, and mentalization are important processes in clinical practice, no self-report measure has been developed to address the psychological construct of self-curiosity. This paper addresses this disparity, and provides a new self-report measure on this topic and data on its nomological network. Curiosity about self was initially conceptualized as the desire tha...

BACKGROUND Periprocedural myocardial infarction (PMI) has had several definitions in the last decade, including the Society for Cardiovascular Angiography and Interventions (SCAI) definition, that requires marked biomarker elevations congruent with surgical PMI criteria. METHODS AND RESULTS The aim of this study was to examine the definition-based frequencies of PMI and whether they influence...